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The PEC technology
Belyntic’s PEC-Linker chemo-selectively catches the desired product from your crude to reach a new dimension of purity.
Overcome the bottleneck in peptide manufacturing and significantly increase your parallelization level of purification.
“For the first time, the Belyntic PEC Kit enabled us to provide peptides that we couldn't purify before.”
Dr. Adrian Glas
Peptide Specialty Laboratories GmbH (PSL)
“[…] our collaboration has highlighted the potential of PEC in either single-step purification or as a pre-LC clean-up step for very complex crude peptide mixtures, making it a valuable addition to our toolbox. The flexible nature of the PEC purification method also provides an additional platform for more unusual peptide chemistry […]”
Dr. Gavin Noble
“With Belyntic's PEC technology, a set of 48 short peptides were rapidly provided, that we were able to use immediately for the development and validation of LC-MS/MS quantification methods. Their team was extremely helpful and responsive. They helped us move a novel project forward very quickly.”
Dr. Alex Kentsis
Memorial Sloan Kettering Cancer Center
“[…] The time saved is precious, enabling technicians to work on other tasks. Also, Belyntic has offered fantastic customer support, with fast communication and great suggestions on how to solve issues to achieve the highest yield and purity.”
Dr. Jonas E. Jensen
“The PEC linker is a significant new invention in peptide synthesis technology, and every peptide chemist can benefit from it. PEC enables all peptide-based biopharmaceutical businesses to considerably increase efficiency in terms of speed and cost of goods, and we expect it to become a standard method of art in peptide production technologies.”
Dr. Thomas Bruckdorfer (CSO & VP Business Development)
Peptides vs Virus
The adaption of the PEC technology to a 96 well-plate format gives fast access to purified peptide libraries. PEC removes most peptidic impurities that may cause false-positive signals and improves sub-sequent screening or the reliability of validation assays. These "PEC-grade" peptide libraries sho...Go to case study
The purification of the hydrophilic peptide Histone H3 (1-20), synthesized via SPPS, is a formidable challenge due to co-eluting impurities. In this study, we show in collaboration with Bachem how to achieve high purities and lower solvent consumption by using the PEC technology and RP-HPLC in a sim...Go to case study
A recently discovered potential 23-mer peptide therapeutic (SBP1) is a binder to the spike protein of the SARS-CoV-2 virus. Easy access to such peptide sequences with options for further modification is essential to support the global efforts in research labs worldwide to fight against emerging dise...Go to case study
20 neoantigens in a single day
The most time-consuming part of the peptide manufacturing process is the purification after synthesis. The PEC technology is a real time-saver at this end. In this case study, we demonstrate the purification of 20 neoantigen peptides with a final average purity of 91% in a single day.Go to case study