At Belyntic, our perpetual goal is to help our customers to focus on the bigger picture of their projects, rather than facing purification issues. To do so, we offer services to tailor our technology to your specific needs.
Coeluting side products often affect peptide purity, producing false-positive results during R&D activities. Our proprietary catch-and-release technology (Peptide Easy Clean, PEC) enables the parallel purification and removal of these critical impurities. Benefit now and increase your assay reliability through our custom synthesis service of PEC-grade peptide libraries.
Highlights of PEC-grade peptide libraries:
> minimum amount of co-eluting truncations and deletion sequences to prevent false-positive results
> low failure rate (< 5%) due to high flexibility for solubilization of hydrophobic and aggregating peptides during purification
> multi-gram scales, modification, and higher purities for subsequent development studies available upon request
|Peptide length||5-20 AA|
|Amount||> 0.5 mg|
Get in touch, and benefit from the highest assay reliability with PEC-grade peptide libraries at unprecedented delivery time and cost.
Every peptide project has a unique complexity profile and needs the highest attention to provide a superior manufacturing route. Belyntic's Peptide Easy Clean (PEC) technology is a groundbreaking tool that enables the fastest and most ecological pathway for peptide production across all peptide projects, regardless of molecule complexity or throughput (e.g., neoantigens).
Highlights of our custom PEC development service:
> we work with the world's leading device manufacturer to offer you an unprecedented automation level at any scale
> our peptide solutions are DMF-free with the lowest possible solvent consumption and waste generation profile
> scale-up in number (e.g., neoantigens) or amount (API) production is ensured with our world-spanning network of CDMO partners
|Peptide type||Linear, cyclic, modified, and other peptidomimetics (PNA) or conjugates|
|Peptide length||10 to >50 AA|
|Throughput||1 to >96 per day|
|Scale||mg to multi-kg|
Get in touch with our team of experts, and we will help you to design the fastest and greenest solution for the ideal peptide drug or therapy.
“For the first time, the Belyntic PEC Kit enabled us to provide peptides that we couldn't purify before.”
Dr. Adrian Glas
Peptide Specialty Laboratories GmbH (PSL)
“[…] our collaboration has highlighted the potential of PEC in either single-step purification or as a pre-LC clean-up step for very complex crude peptide mixtures, making it a valuable addition to our toolbox. The flexible nature of the PEC purification method also provides an additional platform for more unusual peptide chemistry […]”
Dr. Gavin Noble
“With Belyntic's PEC technology, a set of 48 short peptides were rapidly provided, that we were able to use immediately for the development and validation of LC-MS/MS quantification methods. Their team was extremely helpful and responsive. They helped us move a novel project forward very quickly.”
Dr. Alex Kentsis
Memorial Sloan Kettering Cancer Center
“[…] The time saved is precious, enabling technicians to work on other tasks. Also, Belyntic has offered fantastic customer support, with fast communication and great suggestions on how to solve issues to achieve the highest yield and purity.”
Dr. Jonas E. Jensen
“The PEC linker is a significant new invention in peptide synthesis technology, and every peptide chemist can benefit from it. PEC enables all peptide-based biopharmaceutical businesses to considerably increase efficiency in terms of speed and cost of goods, and we expect it to become a standard method of art in peptide production technologies.”
Dr. Thomas Bruckdorfer (CSO & VP Business Development)
Due to solvent waste and energy consumption, the manufacturing of pharmaceutical ingredients has a significant environmental impact. Therefore, the industry demands new and innovative techniques for greener drug production. This study highlights DMF-free solid-phase peptide synthesis (SPPS) and its ...Go to case study
Due to its repetitive cycles of deprotection, washing, and coupling, SPPS is a poorly atom efficient process, resulting in the consumption of a considerable amount of solvents and reagents. Furthermore, typical peptide purification with RP-HPLC also consumes a high amount of organic solvents. In thi...Go to case study
Disulfide formation remains one of the most attractive modification pathways to improve the properties of peptide drugs. The disulfide bridge provides exceptional chemical and conformational stability. However, manufacturing disulfide peptides is challenging, espe¬cially due to unwanted dimer and m...Go to case study
The most time-consuming part of the peptide manufacturing process is the purification after synthesis. The PEC technology is a real time-saver at this end. In this case study, we demonstrate the purification of 20 neoantigen peptides with a final average purity of 91% in a single day.Go to case study